Biotransformation Sr Scientist, Global DMPK
Company: Takeda Pharmaceutical
Location: National City
Posted on: August 5, 2022
Job Description:
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that all information I submit in my employment application is true
to the best of my knowledge. Job Description About the role: The
DMPK department at Takeda, San Diego, CA is seeking a highly
motivated Sr Scientist to join the Biotransformation group. The
primary responsibilities will be profiling and characterization of
metabolites (small molecules, protein degrader, and/or
siRNA)/catabolites (peptides) from complex biological matrices. A
strong background in delineating biotransformation pathways and
structural elucidation by LC-MS is required. A successful candidate
must exhibit strong communication and interpersonal skills and
desire to work in a fast-paced, flexible and dynamic environment.
Experience with in vivo preclinical ADME studies and understanding
of clearance route, mechanism and the role of metabolism/catabolism
is essential. The position level will depend on the level of
experience in the relevant areas. Join Takeda as a
Biotransformation Sr Scientist , based in San Diego, CA. How you
will contribute: ACCOUNTABILITIES
- Identification and structural elucidation of
metabolites/catabolites of small molecules including protein
degrader, siRNA, and peptide drug candidates using LC-MS/MS and
other structure elucidation tools.
- Hands on experience in operation, maintenance & trouble
shooting of LC-MS and other instruments.
- Conduct in vitro drug metabolism studies of small molecules
including protein degrader, siRNA, and peptides.
- Conduct metabolite profiling experiments from in vitro and in
vivo studies
- Work independently, design experiments and report data in
written reports and team presentations as required.
- Maintain accurate records of the study data. Minimum
Requirements/Qualifications:
- Applicants should possess a PhD, MS, or BS in
Organic/Analytical/Natural Products/Protein Chemistry with 3+
(PhD), 9+ years (MS) or 11+ years (BS) of pharmaceutical industry
experience.
- Hands-on experience with HPLC and LC-MS are required.
Familiarity with AB Sciex Q-TOF and/or Thermo Hybrid Orbitrap high
resolution mass spectrometry instruments and metabolite
identification is preferred.
- Good understanding of organic chemistry, structural elucidation
and xenobiotic metabolism required
- Experience in analysis of protein degrader, peptides, and siRNA
by MS is a plus.
- Experience in metabolite/catabolite identification in in vitro
systems (hepatocytes, microsome, etc.) and/or in vivo matrices
(urine, feces, bile and plasma) is required.
- The candidate must be able to analyze data and note significant
deviations and maintain detailed, accurate and comprehensible study
documentation.
- The individual is also expected to be highly organized, a team
player, enthusiastic about drug discovery, and possess strong
communication skills.
- Publications in peer-reviewed scientific journals are required.
What Takeda can offer you:
- Comprehensive Healthcare: Medical, Dental, and Vision
- Financial Planning & Stability: 401(k) with company match and
Annual Retirement Contribution Plan
- Health & Wellness programs including onsite flu shots and
health screenings
- Generous time off for vacation and the option to purchase
additional vacation days
- Community Outreach Programs and company match of charitable
contributions
- Family Planning Support
- Flexible Work Paths
- Tuition reimbursementMore about us:At Takeda, we are
transforming patient care through the development of novel
specialty pharmaceuticals and best in class patient support
programs. Takeda is a patient-focused company that will inspire and
empower you to grow through life-changing work.Certified as a
Global Top Employer, Takeda offers stimulating careers, encourages
innovation, and strives for excellence in everything we do. We
foster an inclusive, collaborative workplace, in which our teams
are united by an unwavering commitment to deliver Better Health and
a Brighter Future to people around the world.In accordance with the
CO Equal Pay Act, Colorado Applicants Are Not Permitted to
Apply.EEO Statement Takeda is proud in its commitment to creating a
diverse workforce and providing equal employment opportunities to
all employees and applicants for employment without regard to race,
color, religion, sex, sexual orientation, gender identity, gender
expression, parental status, national origin, age, disability,
citizenship status, genetic information or characteristics, marital
status, status as a Vietnam era veteran, special disabled veteran,
or other protected veteran in accordance with applicable federal,
state and local laws, and any other characteristic protected by
law. Locations San Diego, CA Worker Type Employee Worker Sub-Type
Regular Time Type Full time
Keywords: Takeda Pharmaceutical, National City , Biotransformation Sr Scientist, Global DMPK, Other , National City, California
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